PSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively.

Product information

CAS Number: 1336913-03-1

Molecular Weight: 404.38

Formula: C18H23F3N2O5

Chemical Name: N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-2,5-dimethoxybenzamide; trifluoroacetic acid

Smiles: COC1=CC=C(C=C1C(=O)N[C@@H]1CN2CCC1CC2)OC.OC(=O)C(F)(F)F

InChiKey: GLKCNNXBIUCCJJ-PFEQFJNWSA-N

InChi: InChI=1S/C16H22N2O3.C2HF3O2/c1-20-12-3-4-15(21-2)13(9-12)16(19)17-14-10-18-7-5-11(14)6-8-18;3-2(4,5)1(6)7/h3-4,9,11,14H,5-8,10H2,1-2H3,(H,17,19);(H,6,7)/t14-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (247.29 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PSEM 89S (10 or 30μM) activates layer 2/3 cortical neurons expressing (Pharmacologically Selective Actuator Module) PSAML141F,Y115F-5HT3 high conductance (HC). PSEM 89S (10 μM) reversibly silenced transfected neurons by reducing cellular input resistance.

In Vivo:

PSEM 89S strongly reduces photostimulation-evoked feeding in mice expressing PSAML141F,Y115F- glycine receptor (GlyR) (30 mg/kg) but not in mice expressing only channelrhodopsin-2 (ChR2) (50 mg/kg). PSEM 89S (30 mg/kg) shows good brain penetrance in mice after minimally invasive intraperitoneal administration.

Products are for research use only. Not for human use.