TAGAP Polyclonal Antibody

Catalogue Numbers: BS61462-50, BS61462-100

Sizes: 50µl, 100µl

Alternative Name: T-cell activation Rho GTPase-activating protein; T-cell activation GTPase-activating protein; TAGAP; TAGAP1; FKSG15

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q8N103

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: TAGAP (T-cell activation Rho GTPase-activating protein) is a 731 amino acid protein that contains one Rho-GAP domain and exists as 4 alternatively spliced isoforms. TAGAP mayfunction as a GTPase-activating protein and may play important roles during T-cell activation. The gene that encodes TAGAP contains approximately 10,685 bases andmapsto human chromosome 6q25.3. Making up nearly 6% of the human genome,chromosome 6 contains around 1,200 geneswithin 170million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is as sociatedwith early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is as sociated with chromosome 6 through the HFE gene. Notably, the PARK2 gene, which is associated with Parkinson’s disease, and the genes encoding the major histocompatiblity complex proteins, are also located on chromosome 6. In addition, Stickler syndrome, hydroxylase deficiency andmaple syrup urine disease are associated with genes on chromosome 6, while a bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TAGAP polyclonal antibody detects endogenous levels of TAGAP protein.

Bioworld Molecular Weight: ~ 82 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of TAGAP polyclonal antibody at 1:500 dilution
Lane 1: Hela whole cell lysate(40ug)
Lane 2: PC12 whole cell lysate(40ug)
Lane 3: RAW264.7 whole cell lysate(40ug)
Lane 4: MCF-7 whole cell lysate(40ug)
Lane 5: H9C2 whole cell lysate(40ug)

Immunogen: Synthetic peptide, corresponding to amino acids 186-231 of Human TAGAP.

Conjugate: Unconjugated

Modification: Unmodified