CD35 Monoclonal Antibody

Catalogue Numbers: MB65777-50, MB65777-100

Sizes: 50µl, 100µl

Product: Mouse IgG1. Liquid in PBS, pH 7.3, and 0.02% sodium azide.

Swiss-Prot: P17927

Host: Mouse

Reactivity: Human

Applications: IF, FC

All Applications: IF (1/50 - 1/200)

Background: Complement receptor type 1`(CR1; CD35) is a type I transmembrane glycoprotein that is expressed on the surface of B cells, neutrophils, monocytes and renal podocytes. As a component of the host innate immune system, CR1/CD35 expressed on neutrophils and monocytes binds to ligands coated with the complement opsonins, C3b and C4b, which facilitates phagocytosis and production of proinflammatory cytokines. CR1/CD35 also participates in negative regulation of the complement cascade through its ability to promote dissociation of C3 and C5 convertases and by serving as one of multiple cofactors for Factor-I-mediated cleavage and inactivation of C3b and C4b.

Purification and Purity: The monoclonal antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes human CD35

Extra Notes: Flow cytometric analysis of human peripheral blood granulocytes using Anti-CD35 Antibody, followed by anti-mouse IgG PE.

Bioworld Molecular Weight: ~ 223 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: C3BR; Complement receptor type 1; C3b/C4b receptor; CD antigen CD35

Immunogen: Native purified human CD35.

Conjugate: Unconjugated

Modification: Unmodified