Nervous System Support Stabilized SAMe, Capsule Form No Enteric Coating Needed Supports Joint Health Non-GMO A Dietary Supplement Vegetarian/Vegan Amino Acids Family Owned Since 1968 GMP Quality Assured SAMe (S-adenosylmethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health. SAMe is critical for the synthesis of neurotransmitters, is important for energy production in the brain, contributes to the maintenance of healthy cell membrane function, and influences cartilage metabolism.