StRIP16, bioavailable StRIP3 analogue, is a double-stapled peptide which can bind to Rab8a GTPase, with a Kd of 12.7 μM.

Product information

Molecular Weight: 2300.61

Formula: C116H154N24O26

Chemical Name: (4S)-4-[[(2S)-2-[[(2S)-2-acetamido-3-carboxypropanoyl]amino]-4-amino-4-oxobutanoyl]amino]-5-[[(3S, 6S, 9S, 12S, 16E, 21S)-21-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(3S, 6S, 9S, 12S, 16E, 21S)-21-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamoyl]-3-(2-amino-2-oxoethyl)-6, 9-dibenzyl-12, 21-dimethyl-2, 5, 8, 11-tetraoxo-1, 4, 7, 10-tetrazacyclohenicos-16-en-12-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl]-9-(3-amino-3-oxopropyl)-3-benzyl-6-(1H-indol-3-ylmethyl)-12, 21-dimethyl-2, 5, 8, 11-tetraoxo-1, 4, 7, 10-tetrazacyclohenicos-16-en-12-yl]amino]-5-oxopentanoic acid

Smiles: CC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@]1(C)CCCC=CCCC[C@](C)(NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CNC3=CC=CC=C23)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@]1(C)CCCC=CCCC[C@](C)(NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)C(=O)N[C@@H](C(C)C)C(N)=O |t:34,122|

InChiKey: DCDBJZCOZBVSRR-ZHSPSBSQSA-N

InChi: InChI=1S/C116H154N24O26/c1-66(2)53-80(106(160)138-114(7)50-30-15-12-13-17-32-52-116(9,112(166)136-95(67(3)4)96(120)150)140-108(162)88(61-92(119)145)132-98(152)81(54-69-33-21-18-22-34-69)127-99(153)82(134-110(114)164)55-70-35-23-19-24-36-70)126-102(156)86(59-74-64-121-65-123-74)130-100(154)83(57-72-41-43-75(142)44-42-72)135-111(165)115(8)51-31-16-11-10-14-29-49-113(6,137-105(159)79(46-48-93(146)147)125-103(157)87(60-91(118)144)131-104(158)89(62-94(148)149)124-68(5)141)109(163)133-78(45-47-90(117)143)97(151)129-85(58-73-63-122-77-40-28-27-39-76(73)77)101(155)128-84(107(161)139-115)56-71-37-25-20-26-38-71/h10-13,18-28,33-44,63-67,78-89,95,122,142H,14-17,29-32,45-62H2,1-9H3,(H2,117,143)(H2,118,144)(H2,119,145)(H2,120,150)(H,121,123)(H,124,141)(H,125,157)(H,126,156)(H,127,153)(H,128,155)(H,129,151)(H,130,154)(H,131,158)(H,132,152)(H,133,163)(H,134,164)(H,135,165)(H,136,166)(H,137,159)(H,138,160)(H,139,161)(H,140,162)(H,146,147)(H,148,149)/b11-10-,13-12-/t78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,95-,113-,114-,115-,116-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

StRIP16 shows selectivity for Rab8 over other Rab-GTPases and does not engage H-Ras or N-Ras (rel. Kd=~10, ~25, ~35, 1.0, ~10, >100, >50, and >100 for Rab1b, Rab5a, Rab6a, Rab8a, Rab9a, Rab11a, H- and N-Ras respectively).

Products are for research use only. Not for human use.