Totti spent his entire career at Roma, winning a Serie Atitle, two Coppa Italia titles, and two Supercoppa Italiana titles. He is the second-highest scorer of all time in Italian league history with 250 goals, and is the sixth-highest scoring Italian in all competitions with 316 goals. Totti is the top goalscorer and the most capped player in Roma's history, holds the record for the most goals scored in Serie A while playing for a single club, and also holds the record for the youngest club captain in the history of Serie A. In November 2014, Totti extended his record as the oldest goalscorer in UEFA Champions League history, aged 38 years and 59 days.

A 2006 FIFA World Cup winner and UEFA Euro 2000finalist with Italy, Totti was selected in the All-Star team for both tournaments; he also represented his country at the 2002 World Cup and Euro 2004. In 2007, Totti announced his international retirement due to recurring physical problems and in order to focus solely on club play with Roma