Eccentric, adventurous Christina Goering meets the anxious but equally enterprising Mrs. Copperfield at a party. Two serious ladies who want to live outside of themselves, they go in search of Mrs. Copperfield who visits Panama with her husband, where she finds solace among the women who live and work in its brothels. Miss Goering becomes involved with various men. At the end the two women meet again, each changed by her experience. Mysterious, profound, anarchic and very funny, 'Two Serious Ladies' is a daring, original work that defies analysis.