Cynomolgus monkeys, a non-human primate (NHP) species native to Southeast Asia, are widely used in biomedical research due to their close genetic and physiological similarity to humans. With a lifespan of approximately 25–30 years, cynomolgus monkeys serve as robust models in toxicology, pharmacology, metabolism, physiology, and neuroscience research. Importantly, many age-related conditions observed in cynomolgus monkeys—such as cardiovascular disease, Alzheimer’s disease, osteoarthritis, obesity, and diabetes—closely parallel those in humans, making them highly relevant for translational studies.

Cynomolgus CD14⁺ monocytes play a central role in innate immune responses. Upon activation, these cells mediate antibody-dependent cellular phagocytosis (ADCP) through the phagocytosis of antibody-opsonized targets and the secretion of inflammatory cytokines. Depending on microenvironmental cues, CD14⁺ monocytes are capable of differentiat

ing into macrophages or dendritic cells, thereby contributing to immune surveillance, antigen presentation, and tissue-specific immune regulation.